ea0026p121 | Female reproduction | ECE2011
Fraser I
, Jensen J
, Schafers M
, Mellinger U
, Parke S
, Serrani M
Introduction: Two identically designed randomized, placebo-controlled double-blind studies (one conducted in North America and the other one in Europe and Australia) showed that an oral contraceptive containing estradiol valerate (E2V)/dienogest (DNG) in an estrogen step-down, progestogen step-up 28-day regimen was effective in women with heavy and/or prolonged menstrual bleeding without organic pathology. Both studies applied a strict definition of treatment succes...